Holmes is an ARC Laureate Fellow, former Premier’s Fellow and Head of the Centre for Computational and Systems Medicine at Murdoch University. having recently moved from Imperial College London where she headed the Division of Computational and Systems Medicine. Her main research area focuses on applying metabolic profiling and computational modelling of biofluids and tissues to understand pathological and physiological disease processes. She has applied the technology in several clinical and biomedical areas but has a strong focus on phenotyping the impact of the gut microbiome on human health. She is a founder director of Melico, a startup company that operates in the personalised nutrition space and is a visiting professor at San Pablo Universidad CEU Madrid, King AbdulAziz University Saudi Arabia and the Chinese Academy of Sciences Wuhan China. She has authored over 500 papers and books in metabolic profiling and chemometrics. She is a Fellow of the Academy of Medical Sciences and has won several awards including the Royal Society of Chemistry Interdisciplinary Award and Lifetime membership of the Metabolomics Society. Her current focus is to develop metabolic profiling capacity in Western Australia and apply it to both population and precision medicine and nutrition.